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This 55 year old man had a sudden loss of consciousness one week ago. When he regained consciousness, he displayed these eye movements.

Review Topic

Can you locate the lesion?

Correct!
This patient cannot perform voluntary eye movements in any direction. But with passive head movement, the eyes do move somewhat in the opposite direction. This dissociation between impaired volitional and intact reflex gaze is called a “supranuclear gaze palsy.” As the gaze deficit is in all directions, the lesion must be in both cerebral hemispheres
  • or both sides of the thalamus.
  • Indeed, he had an episode of severe systemic hypotension that caused a lack of perfusion and oxygenation of both cerebral hemispheres. This phenomenon has been called “acquired ocular motor apraxia,” but the term “apraxia” in this situation is usually reserved for patients who also have elements of Balint-Holmes syndrome, manifesting as difficulty disengaging from viewed targets and misreaching into extrapersonal space. To describe the eye movement abnormality, I prefer to use the term “acquired acute supranuclear gaze disorder.” If the supranuclear nature of the ophthalmoplegia is not recognized, the patient may be misdiagnosed as having myasthenia gravis or polycranial neuropathy. When a supranuclear gaze disturbance develops chronically, the most common cause is progressive supranuclear palsy (PSP). In PSP, vertical gaze is typically more affected than horizontal gaze, and there will be a parkinsonian state.