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This 60 year old man developed body shakes, severe balance difficulty, and blurred vision over a 1-week period.

Review Topic

You would call this abnormality

Correct! The eyes are making conjugate saccades in horizontal, oblique, and vertical planes. The eye movements persist under closed lids. These wild eye movements have been called “saccadomania.” They arise out of disinhibition of brainstem saccadic generators, but the site of damage is unsettled. There are two common settings: post-viral encephalitis and paraneoplastic encephalitis. In children, the tumor of choice is neuroblastoma; in adults, it is small cell lung cancer, but neuroendocrine cancers of many types can cause this. Patients will often also display some combination of impaired thinking, emotional distress, tremor, myoclonus, ataxia, asterixis, and increased deep tendon reflexes. An evaluation for occult tumor is necessary. Treatment with corticosteroids and other immune suppressants is aimed at the neurologic manifestations. However, treatment of an underlying neoplasm may be more effective in relieving these manifestations. If opsoclonus arises as a post-viral phenomenon, it usually resolves completely within months, with or without treatment. If it arises as a paraneoplastic phenomenon, recovery is much less likely, and prognosis depends on the cancer.