Shirley H. Wray, MD, PhD, FRCP

Professor of Neurology Harvard Medical School Director, Unit for Neurovisual Disorders Massachusetts General Hospital

Professor of Neurology Harvard Medical School
Director, Unit for Neurovisual Disorders
Massachusetts General Hospital

Shirley H. Wray Collection

Overview

The Shirley H. Wray Neuro-Ophthalmology Collection consists of videos, clinical notes and related presentations concerning neuro-ophthalmological and neurovisual disorders collected during Dr. Wray’s work as the Director of Neuro-Visual Disorders at Massachusetts General Hospital.

Browse the Wray collection by case number
Browse the Wray collection alphabetically by case title
Complete list of supplementary PowerPoint presentations

Table of Contents

Structure and Functions

  1. The Eyelid
  2. Ocular Motility
  3. Stability Disorders
  4. Movement Disorders of the Face, Head, and Limbs
  5. Visual Cortex

Disease Related Disorders of the Central Nervous System

  1. Degenerative CNS Diseases
  2. Paraneoplastic
  3. Demyelination
  4. Muscle and Neuromuscular Junction
  5. Infection
  6. Vascular Disease/Stroke
  7. Cerebellum
  8. Stupor and Coma

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Structure & Functions

I. The Eyelid

Section 1: Closure and Stability Disorders

  1. Apraxia
  2. Blepharoclonus
  3. Blepharospasm
  4. Blinking Voluntary
  5. Lid Flutter
  6. Lid Lag
  7. Lid Nystagmus
  8. Lid Retraction
  9. Lid Twitch
  10. Lid Winking
  11. Positive Glabella Tap
  12. Eyebrow Spasms

Section 2: Ptosis

  1. Unilateral
    1. Congenital Ptosis
    2. Voluntary Ptosis
    3. Third Nerve Palsy (Oculomotor)
    4. Fascicular Third Nerve Palsy
    5. Aberrant Reinnervation of the Third Nerve
    6. Progressive External Ophthalmoplegia
    7. Myasthenia Gravis
      1. Tensilon Test
  2. Bilateral
    1. Nuclear Third Nerve Palsy
    2. Progressive External Ophthalmoplegia
    3. Myasthenia Gravis
    4. Guillain Barre Syndrome – Miller Fisher Syndrome

II. Ocular Motility

Section 1: Muscle and Neuromuscular Junction

  1. Restrictive Orbitopathy
  2. Myasthenia Gravis
    1. Ocular Myasthenia Gravis
    2. Generalized Myasthenia Gravis
    3. MuSK Antibody Myasthenia Gravis
  3. Progressive External Ophthalmoplegia
  4. Acute Inflammatory Demyelinating Neuropathy (Miller Fisher Syndrome)

Section 2: Cranial Nerve

  1. Third Nerve
    1. Nuclear
    2. Unilateral
  2. Fourth Nerve Palsy
    1. Unilateral
  3. Sixth Nerve Palsy
    1. Unilateral
    2. Bilateral
  4. Multiple Ocular Motor Nerve Palsies
    1. Cavernous Sinus Syndrome

Section 3: Nuclear

  1. Third Nerve – Oculomotor Nucleus
  2. Sixth Nerve – Abducens Nucleus
    1. Congenital – Duane’s Syndrome

Section 4: Internuclear

  1. Unilateral Internuclear Ophthalmoplegia
  2. Bilateral Internuclear Ophthalmoplegia
  3. Fisher’s One and a Half Syndrome
  4. Pseudo-Internuclear Ophthalmoplegia

Section 5: Supranuclear

  1. Vertical
    1. Upgaze
      1. Infarct
      2. Hemorrhage
      3. Degeneration
      4. Infection
        1. AIDS -Encephalitis
      5. Increased Intracranial Pressure
      6. Pineal Region Tumor
    2. Downgaze
      1. Infarct
      2. Encephalopathy
    3. Up and Downgaze
      1. Infarct
      2. Degeneration
      3. Infection
        1. Whipple’s Disease
    4. Skew Deviation
      1. Infection
        1. Ocular Tilt Reaction
        2. Paroxysmal Skew Deviation
  2. Horizontal Gaze Disorders
    1. Unilateral Gaze Palsy
      1. Pontine Lesions
        1. Infarct
        2. Hemorrhage
        3. Demyelination
        4. Metastasis
    2. Bilateral Gaze Palsy
      1. Congenital
      2. Pontine Lesions
        1. Hemorrhage
        2. Hypoxia
    3. Slow Hypometric Horizontal Saccades
      1. Degeneration
    4. Lateropulsion

Section 6: Central Disorders

  1. Cortical
    1. Horizontal Gaze
      1. Ocular Motor Apraxia
        1. Congenital
        2. Aquired

Section 7: Vergence Movements

  1. Convergence Insufficiency
  2. Spasm of the Near Reflex

III. Stability Disorders

Section 1: Spontaneous Intrusions Oscillations

  1. Opsoclonus
    1. Neonatal
    2. Parainfectious Opsoclonus
    3. Paraneoplastic
  2. Ocular Flutter
    1. Neonatal
    2. Idiopathic
    3. Paraneoplastic
    4. Multiple Sclerosis
  3. Square Wave Jerks
  4. Jerk Oscillations
  5. Pendular Vertical Oscillations
  6. Pendular Horiztonal Oscillations
  7. Ocular Dipping

Section 2: Rhythmic Intrusions/Nystagmus/Dysmetria

  1. Congenital Nystagmus
    1. Infantile Nystagmus Syndrome
      1. Familial Congenital Nystagmus
      2. Horizontal Pendular Nystagmus
      3. Horizontal Jerk Nystagmus
    2. Fusional Maldevelopment Nystagmus Syndrome
      1. Latent
  2. Nystagmus – Acquired
    1. Vertical
      1. Upbeat
        1. Primary Position
        2. Gaze Evoked
      2. Downbeat
        1. Primary Position
        2. Gaze Evoked
    2. Horizontal
      1. Primary Position
      2. Gaze Evoked
    3. Special Forms
      1. Abducting
      2. Elliptical
      3. Periodic Alternating
      4. Rebound
      5. See-saw
      6. Torsional
      7. Voluntary
    4. Vergence Nystagmus
      1. Ocular Dipping
      2. Pendular Vergence Oscillations
  3. Saccadic Dysmetria
    1. Vertical
    2. Horizontal
  4. Oscillopsia

IV. Movement Disorders of the Face, Head, and Limbs

  1. Blepharospasm
  2. Hemifacial Spasm
  3. Facial Tremor
  4. Eyebrow Spasms
  5. Facial Weakness
  6. Marcus-Gunn Jaw Winking
  7. Oculomasticatory Myorhythmia
  8. Palatal Tremor
  9. Titubation
  10. Head Thrust
  11. Ataxia

V. Visual Cortex

  1. Homonymous Hemaniopia: Alexia without Agraphia
  2. Release Hallucinations
  3. Palinopsia
  4. Migraine
    1. Visual Aura

PowerPoint Presentations

PowerPoint Slides from Wray Collection

  1. Alcoholic Cerebellar Degeneration
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  2. Alexia without Agraphia
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  3. Alzheimer’s Disease
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  4. Amyotrophic Lateral Sclerosis
    Robert H. Brown, Jr.D. Phil. M.D.
    Professor and Chair of Neurology
    University of Massachusetts Medical Center
  5. Bilateral Internuclear Ophthalmoplegia
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  6. Bilateral Ptosis
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  7. Blepharospasm Round Up
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  8. Brain Control of Horizontal Saccadic Eye Movements
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  9. Brain MRI in Multiple Sclerosis
    Anne G. Osborn, M.D.
    Distinguished Professor of Radiology
    William H. and Patricia W. Child
    Presidential Endowed Chair in Radiology
    University of Utah School of Medicine
  10. Brainstem Cavernous Angioma
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  11. Cavernous Angioma
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  12. Cavernous Sinus Meningioma
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  13. Charles Bonnet Syndrome
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  14. Chest CT Thymoma
    Robert A. Novelline, M.D.
    Professor of Radiology, Harvard Medical School
    Director of Emergency Radiology
    Massachusetts General Hospital
  15. Chiari I Malformation
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  16. Childhood Migraine disease
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  17. Claude’s Syndrome
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  18. Clivus Chordoma
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  19. CNS Lymphoma
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  20. Congenital Horizontal Gaze Palsy Progressive Scoliosis
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  21. Constructional Apraxia
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  22. Convergence Insufficiency
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  23. Downbeat Nystagmus
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  24. Downbeat Nystagmus PAN
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  25. Essential Palatal Tremor
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  26. Eyebrow Spasm
    Daniel J. Costello, M.D.
    Neurologist
    Ballinacragga Foynes
    County Limerick Ireland
  27. Familial Amyotrophic Lateral Sclerosis
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  28. Frontotemporal Dementia
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  29. Hemifacial Spasm
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  30. Horizontal Gaze Palsy
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  31. Internuclear Ophthalmoplegia in Childhood
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  32. Lateropulsion
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  33. Lessons from the Bench and Bedside
    Stephen L. Hauser, M.D.
    Professor and Chair of Neurology
    University of California, San Francisco
  34. Lid Lag
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  35. Midbrain Hemorrhage
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  36. Migraine Visual Aura
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  37. Miller Fisher Syndrome
    Sarah I. Sheikh, BM. BCh. MRCP
    Postgraduate Fellow in Neuromuscular Disease
    Massachusetts General Hospital
  38. Mitochondrial Myopathy
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  39. Movement Disorders: A Brief Overview
    Albert Yung-Pai Hung, M.D. Ph.D.
    Instructor in Neurology
    Massachusetts General Hospital
  40. Multiple Sclerosis
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  41. Multiple Sclerosis Lateropulsion
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  42. Myasthenia Gravis
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  43. Myasthenia Thymoma
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  44. Neuroblastoma
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  45. Ocular Motor Apraxia
    Shirley H. Wray, M.D. Ph.D. FRCP
    The Carol F. Zimmerman Lecture 2007
    Harvard Medical School
  46. Ocular Myasthenia Gravis: Past, Present and Future
    Victoria S. Pelak, M.D.
    Associate Professor of Neurology
    University of Colorado Health Sciences Center
  47. Oculomasticatory Myorhythmia
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  48. One and a Half Syndrome
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  49. Overview of TDP-43 Proteinopathy: Shared Mechanisms Underlying Frontotemporal Lobar Degeneration and Amyotrophic
    Lateral Sclerosis
    The F. E. Bennett Lecture
    American Neurologic Association 2008

    John Q. Trojanowski, M.D. Ph.D.
    Professor of Pathology and Laboratory Medicine
    Co-Director, Center for Neurodegenerative Disease Research
    University of Pennsylvania
  50. Palatal Tremor
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  51. Paraneoplastic Ocular Flutter
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  52. Paraneoplastic Opsocolonus
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  53. Paraneoplastic Upbeat Nystagmus
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  54. Parasellar Meningioma
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  55. Parkinson’s Disease
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  56. Pendular Horizontal Oscillations
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  57. Pendular Vertical Oscillations
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  58. Pontine Infarction
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  59. Progressive External Ophthalmoplegia
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  60. Progressive Supranuclear Palsy
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  61. Saccades and Saccadic Oscillations
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  62. Selective Saccadic Palsy
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  63. Supranuclear Paralysis of Downgaze
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  64. Supranuclear Paralysis of Vertical Gaze
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  65. Tauopathies: A Contemporary Way to Consider a Set of Neurodegenerative Disease Based on Molecular Signature
    John Growdon, M.D.
    Professor of Neurology
    Memory Disorder Unit
    Massachusetts General Hospital
  66. Thalamic Infarct
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  67. Thalamic Stroke and Disordered Sleep
    Kenneth C. Sassower, M.D.
    Instructor in Neurology
    Division of Clinical Neurophysiology
    Massachusetts General Hospital
  68. Third Nerve Palsy
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  69. Thyroid Associated Orbitopathy
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  70. Transient Monocular Blindness
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  71. Upbeat Nystagmus
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  72. Visual Neglect
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School
  73. Whipple’s Disease
    Shirley H. Wray, M.D. Ph.D. FRCP
    Harvard Medical School

Career

Shirley H. Wray, M.D., Ph.D., FRCP
Professor of Neurology Harvard Medical School
Director, Unit for Neurovisual Disorders
Massachusetts General Hospital

Articles in PubMed